Effect of CD4+ T-Cells and CD8+ T-Cells on Psoriasis: a mathematical study

Abstract

Psoriasis is a common chronic inflammatory skin disease that is differentiated by repeated occurrences of raised scaly and red skin plaques. It is generated through several applications of drugs, strains, physical wounds to the skin and also for infectivity. Psoriasis is identified by composite interactions of T-Cells, Dendritic Cells, Cytokines and downstream transcription factors (type 1 Cytokines network). The effects of T-Cells in dermal layer (CD4+ T-Cells) are well-studied in the disease dynamics of Psoriasis from mathematical as well as biological context. But the concept of T-Cells in epidermal layer (CD8+ T-Cells) for disease progression of Psori-asis has not yet been explored till now from mathematical avenue. Here we introduce both CD4+ and CD8+ T-Cell, Dendritic Cell and Keratinocyte population to notice the impact of them on immunopathogenic cell-biological mechanism of Psoriasis. Numerical simulation is also furnished to establish the analytical outcomes.