Using copulas to select prognostic genes in melanoma patients

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dc.contributor.authorChaba, Linda
dc.contributor.authorOdhiambo, John
dc.contributor.authorOmolo, Bernard
dc.date.accessioned2017-10-23T12:30:01Z
dc.date.available2017-10-23T12:30:01Z
dc.date.issued2017
dc.description.abstractMelanoma of the skin is the fifth and seventh most commonly diagnosed carcinoma in men and women, respectively, in the USA. So far, gene signatures prognostic for overall and distant metastasis-free survival, for example, have been promising in the identification of therapeutic targets for primary and metastatic melanoma. But most of these gene signatures have been selected using statistics that depend entirely on the parametric distributions of the data (e.g. t-statistics). In this study, we assessed the impact of relaxing the parametric assumptions on the power of the models used for gene selection. We developed a semi-parametric model for feature selection that does not depend on the distributions of the covariates. This copula-based model only assumed that the marginal distributions of the covariates are continuous. Simulations indicated that the copula-based model had reasonable power at various levels of the false discovery rate (FDR). These results were validated in a publicly-available melanoma dataset. Relaxing parametric assumptions on microarray data may yield procedures that have good power for differential gene expression analysis.en_US
dc.identifier.urihttp://hdl.handle.net/11071/5500
dc.language.isoen_USen_US
dc.publisherLife science Globalen_US
dc.subjectCopulaen_US
dc.subjectFalse discovery rateen_US
dc.subjectMelanomaen_US
dc.subjectMicroarrayen_US
dc.subjectPower.en_US
dc.titleUsing copulas to select prognostic genes in melanoma patientsen_US
dc.typeArticleen_US
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