Mathematical modelling of Hepatitis E Virus (HEV) and Chronic Myeloid Leukemia (CML) co-infection dynamics

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dc.contributor.authorKatakara, Denis Kagyera
dc.contributor.authorFaraimunashe, Uganda Chirove
dc.date.accessioned2021-05-10T07:09:44Z
dc.date.available2021-05-10T07:09:44Z
dc.date.issued2017
dc.descriptionPaper presented at the 4th Strathmore International Mathematics Conference (SIMC 2017), 19 - 23 June 2017, Strathmore University, Nairobi, Kenya.en_US
dc.description.abstractThere are major advances which have been made to understand HEV and CML transmission dynamics but none of these have considered the effects of transmission parameters on the burden of HEV on CML prevalence in a co-infection scenario. In this paper we formulated a mathematical model for the co-infection of HEV and CML using a system of ordinary differential equations, in order to understand the effects of the co-infection on HEV and CML and vice versa in a human population. The model was analysed and steady state conditions were derived. Our results showed that the disease free equilibrium was both locally stable and globally stable if the basic reproduction number, R0 ≤ 1 and unstable if the basic reproduction number, R0 > 1. Our results also suggest that, (i) HEV reduces the CML infectives and accelerates the co-infection, (ii) CML enhances the progression of both HEV infection and the co-infection and, (iii) there is an increase in HEV-CML burden due to coinfection compared to single infections of either HEV or CML.en_US
dc.description.sponsorshipMbarara University of Science and Technology, Mbarara, Kwa-Zulu University, Natal, South Africaen_US
dc.identifier.urihttp://hdl.handle.net/11071/10490
dc.language.isoenen_US
dc.publisherStrathmore Universityen_US
dc.subjectHepatitis E Virus (HEV)en_US
dc.subjectChronic Myeloid Leukemia (CML)en_US
dc.subjectBasic reproduction numberen_US
dc.subjectCo-infectionen_US
dc.titleMathematical modelling of Hepatitis E Virus (HEV) and Chronic Myeloid Leukemia (CML) co-infection dynamicsen_US
dc.typeArticleen_US
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