Intracellular and immune-response delays effects on the interaction between tumor cells, oncolytic viruses and the immune system

Simple item page
dc.contributor.authorOuifki, R.
dc.contributor.authorChabaari, W.
dc.contributor.authorEladdadi, A.
dc.date.accessioned2021-05-10T09:05:23Z
dc.date.available2021-05-10T09:05:23Z
dc.date.issued2017
dc.descriptionPaper presented at the 4th Strathmore International Mathematics Conference (SIMC 2017), 19 - 23 June 2017, Strathmore University, Nairobi, Kenya.en_US
dc.description.abstractBackground: Oncolytic viruses are used as a form of cancer treatment since they lyse the tumor cells whilst leaving normal cells largely unharmed. The oncolytic effect depends on both the viral replication ability as well as the type of immune response induced by the said replication. One major challenge to this therapy is the delays that can occur during viral replication combined with a fast immune response. Aim: We therefore aim at investigating the possible trade-offs between the tumor cells, oncolytic viruses and the immune systems with particular focus will be on the simultaneous effects of these two delays. Methods: We extend recently published mathematical models on viro therapy by taking into account the simultaneous effects of the two delays and considering various forms of virus cell infections; namely mass-action, frequency- dependent and Holing-type. We investigate the models’ stability and bifurcation behaviour and then fit them to data. Consequently, carry out numerical simulations to explore various scenarios of model treatment Results: We derived an explicit formula for the trade off between the two delays that leads to tumor eradication. One of the main findings is the occurrence of delay-induced Hopf bifurcation, indicative of tumor relapse.en_US
dc.description.sponsorshipUniversity of Pretoria,University of Stellenbosch, Stellenbosch, South Africa
dc.identifier.urihttp://hdl.handle.net/11071/10493
dc.language.isoenen_US
dc.publisherStrathmore Universityen_US
dc.subjectIntracellularen_US
dc.subjectTumor cellsen_US
dc.subjectOncolytic virusesen_US
dc.subjectImmune systemen_US
dc.titleIntracellular and immune-response delays effects on the interaction between tumor cells, oncolytic viruses and the immune systemen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Intracellular and immune-response delays effects on the interaction between tumor cells, oncolytic viruses and the immune system.pdf
Size:
66.82 KB
Format:
Adobe Portable Document Format
Description:
Abstract - SIMC Conference paper, 2017
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
SIMC 2017