Mathematical models for Hepatocytic-Erythrocytic dynamics and therapeutic control of Malaria

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dc.contributor.authorOrwa, Titus O.
dc.contributor.authorMbogo, Rachel W.
dc.contributor.authorLuboobi, Livingstone S.
dc.date.accessioned2021-05-07T08:29:05Z
dc.date.available2021-05-07T08:29:05Z
dc.date.issued2017
dc.descriptionPaper presented at the 4th Strathmore International Mathematics Conference (SIMC 2017), 19 - 23 June 2017, Strathmore University, Nairobi, Kenya.en_US
dc.description.abstractMalaria is one of the most frequently occurring infectious diseases worldwide (along with HIV/AIDS and tuberculosis), with almost 1 million deaths and an estimated 243 million clinical cases annually. An in-host model of malaria that describes the dynamics of the malaria parasite in the liver and blood stages and its interaction with liver cells, red blood cells and immune effectors is proposed. Conditions for existence of the diseases free equilibrium are derived. An in-host basic reproductive number is derived based on the next generation matrix method. For effective control of parasitemia, controls (antimalarials and vaccines) should target both the sporozoite and merozoite at the liver and blood stages respectively.en_US
dc.identifier.urihttp://hdl.handle.net/11071/10451
dc.language.isoenen_US
dc.publisherStrathmore Universityen_US
dc.subjectIn-hosten_US
dc.subjectHepatocytesen_US
dc.subjectErythrocytesen_US
dc.subjectImmune cellsen_US
dc.subjectMerozoitesen_US
dc.subjectSporozoitesen_US
dc.titleMathematical models for Hepatocytic-Erythrocytic dynamics and therapeutic control of Malariaen_US
dc.typeArticleen_US
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