Numerical solution for an extended multi-mutation and drug resistance model
Date
2019-08
Authors
Kolade, Mathew Owolabi
Kailash, Chandra Patidar
Shikongo, Albert
Journal Title
Journal ISSN
Volume Title
Publisher
Strathmore University
Abstract
In this study, we extend a model that expresses intrinsic drug resistances to include SBS
time required for mutation rate to take place and spatial effects of the involved cells.
Furthermore, we show that the local stability condition(s) are (is) global stable. Since it
is not that easy to solve the extended model analytically, we derive, analyze, implement,
present a numerical solution and compare it with the solution of the original model.
Description
Paper presented at the 5th Strathmore International Mathematics Conference (SIMC 2019), 12 - 16 August 2019, Strathmore University, Nairobi, Kenya
Keywords
Mutations, Chemotherapy, Stability analysis., Drug resistance