Array-based schemes for group screening with test errors which incorporate a concentration effect

Odhiambo, John W.; Mwambi, H.G.; Haines, Linda M.; Habtesllassie, Y.G.

Publication:
Array-based schemes for group screening with test errors which incorporate a concentration effect

dc.contributor.author	Odhiambo, John W.
dc.contributor.author	Mwambi, H.G.
dc.contributor.author	Haines, Linda M.
dc.contributor.author	Habtesllassie, Y.G.
dc.date.accessioned	2015-08-11T08:34:21Z
dc.date.available	2015-08-11T08:34:21Z
dc.date.issued	2015-06-04
dc.description.abstract	Group screening is widely used as an efficient method for identifying samples or factors from a large population that are in some sense active. The focus in the present paper is on screening blood samples for infectious diseases when errors in testing are present. Specific attention is given to the introduction of a concentration effect, that is to settings in which the error in testing a group of blood samples depends on the number of samples in that group which are infected. Four array-based group screening schemes, the Dorfman, the and, the or and a modification of the and scheme, are considered and their performance appraised by deriving explicit formulae for the expected number of tests, the expected number of false negatives and the expected number of false positives. The results are illustrated by means of two examples. As an aside, relationships complementary to those derived in the context of blood screening are developed within the area of group factor screening.	English
dc.description.sponsorship	Group screening is widely used as an efficient method for identifying samples or factors from a large population that are in some sense active. The focus in the present paper is on screening blood samples for infectious diseases when errors in testing are present. Specific attention is given to the introduction of a concentration effect, that is to settings in which the error in testing a group of blood samples depends on the number of samples in that group which are infected. Four array-based group screening schemes, the Dorfman, the and, the or and a modification of the and scheme, are considered and their performance appraised by deriving explicit formulae for the expected number of tests, the expected number of false negatives and the expected number of false positives. The results are illustrated by means of two examples. As an aside, relationships complementary to those derived in the context of blood screening are developed within the area of group factor screening.	en_US
dc.identifier.issn	0378-3758
dc.identifier.uri	http://hdl.handle.net/11071/4036
dc.identifier.uri	http://dx.doi.org/10.1016/j.jspi.2015.05.009
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.subject	Array	en_US
dc.subject	Group testing	en_US
dc.subject	Factors	en_US
dc.subject	False negatives	en_US
dc.subject	False positives	en_US
dc.subject	Sensitivity	en_US
dc.subject	Specificity	en_US
dc.title	Array-based schemes for group screening with test errors which incorporate a concentration effect	en_US
dc.type	Article	en_US
dspace.entity.type	Publication