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Stochastic Model for Langerhans cells and HIV Dynamics in Vivo
Mbogo, Rachel Waema; Luboobi, Livingstone S.; Odhiambo, John W.
Many aspects of the complex interaction between HIV and the human immune system remain elusive. Our objective is to study these inter-actions, focusing on the speci c roles of langerhans cells (LCs) in HIV infection. In patients infected with HIV, a large amount of virus is as-sociated with LCs in lymphoid tissue. To assess the influence of LCs on HIV viral dynamics during anti-retroviral therapy, we present and analyse a stochastic model describing the dynamics of HIV, CD4+ T-cells, and LCs interactions under therapeutic intervention in vivo. We per-form sensitivity analyses on the model to determine which parameters and/or which interaction mechanisms strongly affect infection dynamics.