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Using copulas to select prognostic genes in melanoma patients
(Strathmore University, 2017)
Melanoma of the skin is the 5th and seventh most commonly diagnosed carcinoma in men and women, respectively, in the USA. So far, gene signatures prognostic for overall and distant metastasis-free survival, for example, ...
Validation of the smooth test of goodness-of-fit for proportional hazards in Cancer survival studies
(Strathmore University, 2017)
In this study, we validate the smooth test of goodness-of-fit for the proportionality of the hazard function in the two-sample problem in cancer survival studies. The smooth test considered here is an extension of Neyman’s ...
Adaptation of a RAS pathway activation signature from FF to FFPE tissues in colorectal cancer
(Strathmore University, 2017)
Background: The KRAS gene is mutated in about 40 % of colorectal cancer (CRC) cases, which has been clinically validated as a predictive mutational marker of intrinsic resistance to anti-EGFR inhibitor (EGFRi) therapy. ...
Spatiotemporal Bayesian Technique to gap-fill and downscale long-term vegetation index records
(Strathmore University, 2017)
Long-term Earth observation based vegetation index records are used extensively to characterize the environmental and ecosystem response to climate variability and change. However, the presence of clouds, and other spectral ...