Stochastic Model for Langerhans cells and HIV Dynamics in Vivo

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dc.creatorMbogo, Rachel Waema
dc.creatorLuboobi, Livingstone S.
dc.creatorOdhiambo, John W.
dc.dateWed, 11 Sep 2013 14:15:07
dc.dateWed, 11 Sep 2013 14:15:07
dc.date.accessioned2015-03-18T11:29:06Z
dc.date.available2015-03-18T11:29:06Z
dc.descriptionWorking paper
dc.descriptionMany aspects of the complex interaction between HIV and the human immune system remain elusive. Our objective is to study these inter-actions, focusing on the specic roles of langerhans cells (LCs) in HIV infection. In patients infected with HIV, a large amount of virus is as-sociated with LCs in lymphoid tissue. To assess the influence of LCs on HIV viral dynamics during anti-retroviral therapy, we present and analyse a stochastic model describing the dynamics of HIV, CD4+ T-cells, and LCs interactions under therapeutic intervention in vivo. We per-form sensitivity analyses on the model to determine which parameters and/or which interaction mechanisms strongly affect infection dynamics.
dc.description.abstractMany aspects of the complex interaction between HIV and the human immune system remain elusive. Our objective is to study these inter-actions, focusing on the speci c roles of langerhans cells (LCs) in HIV infection. In patients infected with HIV, a large amount of virus is as-sociated with LCs in lymphoid tissue. To assess the influence of LCs on HIV viral dynamics during anti-retroviral therapy, we present and analyse a stochastic model describing the dynamics of HIV, CD4+ T-cells, and LCs interactions under therapeutic intervention in vivo. We per-form sensitivity analyses on the model to determine which parameters and/or which interaction mechanisms strongly affect infection dynamics.
dc.identifier.urihttp://hdl.handle.net/11071/3681
dc.subjectHIV infection
dc.subjectLatent period
dc.subjectLangerhans cells
dc.subjectCD4+ T cells
dc.subjectStochastic model
dc.subjectTherapeutic intervention
dc.titleStochastic Model for Langerhans cells and HIV Dynamics in Vivo
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